Pharmacokinetic and Pharmacodynamic Evaluation of Marbofloxacin in Pig against Korean Local Isolates of Actinobacillus pleuropneumoniae

Table 3

Pharmacokinetic parameters of marbofloxacin following intravenous, intramuscular, and peroral administration using WinNonlin (, mean ± SD).

Parameters	Unit	i.v.	i.m.	p.o.
	h	8.60 ± 0.30	12.8 ± 1.10	8.60 ± 0.00
	h	0.25 ± 0.00	0.44 ± 0.10	1.58 ± 0.40
	µg/mL	2.60 ± 0.10	2.59 ± 0.12	2.34 ± 0.12
	h⋅µg/mL	24.80 ± 0.90	25.8 ± 1.40	23.40 ± 5.00
	%	—	104.60 ± 5.70	94.35 ± 8.90

i.v.: intravenous, i.m.: intramuscular, p.o.: peroral, and : elimination half-life. : time of maximum concentration; : maximum concentration after administration; : area under the serum concentration-time curve from time zero to 24 h; and : bioavailability. Significantly different among groups.