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BioMed Research International
Volume 2017 (2017), Article ID 2483264, 15 pages
https://doi.org/10.1155/2017/2483264
Review Article

Comparative Study of Elastic Network Model and Protein Contact Network for Protein Complexes: The Hemoglobin Case

1Center for Systems Biology, School of Electronic and Information Engineering, Soochow University, Suzhou 215006, China
2Unit of Chemical-Physics Fundamentals in Chemical Engineering, Department of Engineering, Università Campus Bio-Medico di Roma, Rome, Italy
3Environment and Health Department, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Roma, Italy

Correspondence should be addressed to Guang Hu

Received 22 June 2016; Revised 17 November 2016; Accepted 20 December 2016; Published 22 January 2017

Academic Editor: Hesham H. Ali

Copyright © 2017 Guang Hu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Figure S1 (a) shows that R2-Hb demonstrates different intrinsic dynamics with T-HB, and Figure S1 (b) detects that the second ANM mode of T-Hb contribute the most for the conformational change from T-state to R2 state. Figure S1 (c) shows that R2-Hb has similar intrinsic dynamics with R-Hb. Distribution of mean-square fluctuations shown in Figure S1 (d) further found that R2-Hb has similar intrinsic flexibilities with R-Hb, but different with T-Hb.

  1. Supplementary Material