Mutagenic and Cytotoxicity LQB 123 Profile: Safety and Tripanocidal Effect of a Phenyl-t-Butylnitrone Derivative

Figure 1

LQB 123 decreases T. cruzi infection. (a) The percentage of infection, (b) the number of parasites/macrophage, and (c) the infection index. The infection index was determined by the percentage of infected cells multiplied by the number of parasites per cell. (d) Light microscopy of T. cruzi infected macrophages after 3 days. The cells were stained by quick Romanowsky-type stain (Panótico Rápido LB) and examined under a light microscope at 100x magnification. Scale bars = 10 μm. The data from DMSO represents the concentration present in the highest dose of the drug. Results are shown as mean ± SD; represents in relation to the control group by ANOVA one-way test and Tukey’s posttest. Data are representative of three independent experiments performed in triplicate.

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