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BioMed Research International
Volume 2017, Article ID 2484303, 11 pages
https://doi.org/10.1155/2017/2484303
Research Article

Dab1 Contributes to Angiotensin II-Induced Apoptosis via p38 Signaling Pathway in Podocytes

Division of Nephrology, Renmin Hospital of Wuhan University, 238 Jiefang Rd., Wuhan, Hubei 430060, China

Correspondence should be addressed to Guohua Ding; moc.liamg@gnidxhg

Received 4 February 2017; Revised 16 April 2017; Accepted 10 May 2017; Published 5 June 2017

Academic Editor: Deepak Nihalani

Copyright © 2017 Zhao Gao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Numerous studies have found that angiotensin II (Ang II) participates in podocyte apoptosis and exacerbates progression of end-stage kidney disease (ESKD). However, its underlying mechanism remains largely unexplored. As a homolog of Drosophila disabled (Dab) protein, Dab1 plays a vital role in cytoskeleton, neuronal migration, and proliferation. In the present study, our data revealed that Ang II-infused rats developed hypertension, proteinuria, and podocyte injury accompanied by Dab1 phosphorylation and increased reelin expression in kidney. Moreover, Ang II induced podocyte apoptosis in vitro. Dab1 phosphorylation and reelin expression in podocytes were increased after exposure to Ang II. Conversely, Dab1 small interfering RNA (siRNA) exerted protective effects on Ang II-induced podocyte apoptosis, resulting in decreased p38 phosphorylation and reelin expression. These results indicated that Dab1 mediated Ang II-induced podocyte apoptosis via p38 signaling pathway.