Anti-Parkinson Drug Biperiden Inhibits Enzyme Acetylcholinesterase

Table 2

Found results about biperiden interaction with AChE.

Parameter	Findings
Mechanism of inhibition	Uncompetitive
Inhibition constant (equal to IC50 in this kind of inhibition)	1.11 ± 0.20 mmol/l
Predicted binding energy	−7.84 kcal/mol
Predicted interactions	H-bond: Tyr 341; π-π interaction: Tyr 72, Trp 286, Tyr 341