Stellate Cell Activation and Imbalanced Expression of TGF-β1/TGF-β3 in Acute Autoimmune Liver Lesions Induced by ConA in Mice

Figure 2

Major organ morphology and histopathology. In the control group, the hepatic lobules of the mice in the control group were normal and clear, the hepatic cord was well arranged, and the central veins were not congested (a). Mild hyperemia occurred in the 2 h group, mild lymphocyte infiltration occurred in the portal area, and mild steatosis occurred in the hepatocytes 2 h after ConA injection (b). 8 h after ConA injection, liver congestion and disappearance of hepatic sinusoid and hepatic cords (c). Cell steatosis and a large number of inflammatory cells’ infiltration in the portal area (d) were observed. Liver congestion, hepatocellular degeneration, infiltration of inflammatory cell in the portal area, and hepatic parenchyma (e). Liver damage showed recovering trend 48 h after ConA injection, with no significant inflammatory infiltration in the portal area (f).

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