Interaction of MRE11 and Clinicopathologic Characteristics in Recurrence of Breast Cancer: Individual and Cumulated Receiver Operating Characteristic Analyses

Table 2

AUC of clinicopathologic characteristics for recurrence status.

Variable	AUC	High risk	Low risk	Sensitivity	Specificity
Tumor size (cm)	0.679	≥2.4 cm	<2.4 cm	0.677	0.682
Stage	0.671	II, III	I	0.941	0.400
ER	0.651	Negative	Positive	0.588	0.714
HT	0.645	No	Yes	0.618	0.673
LN metastasis	0.633	Positive	Negative	0.588	0.677
Age	0.625	≥52 yrs	<52 yrs	0.677	0.573
PR	0.619	negative	positive	0.647	0.591
MRE11 positive cells	0.592	>50%	≤50%	0.853	0.332
BMI	0.566	≥24	<24	0.559	0.573
HER2 status	0.535	Negative	Positive	0.706	0.364
Grade	0.524	3	1, 2	0.294	0.755
CT	0.505	No	Yes	0.147	0.864
RT	0.396	No	Yes	0.206	0.586

Data for high/low risks of breast cancer recurrence were retrieved from our previous study [9]. AUC: area under receiver operating characteristic; ER: estrogen receptor; HT: hormone therapy; LN: lymph node; PR: progesterone receptor; MRE11: meiotic recombination 11; BMI: body mass index; HER2: human epidermal growth factor receptor 2; CT: chemotherapy; RT: radiotherapy.