Interaction of MRE11 and Clinicopathologic Characteristics in Recurrence of Breast Cancer: Individual and Cumulated Receiver Operating Characteristic Analyses

Table 4

Cut-off point identified by ROC analysis.

Number of; dichotomized; variables	Sensitivity	Specificity	Sensitivity +; specificity	Correctly classified	LR+	LR−
0	1.000	0.000	1.000	0.134	1.000	—
1	1.000	0.027	1.027	0.158	1.028	0.000
2	1.000	0.073	1.073	0.197	1.078	0.000
3	1.000	0.182	1.182	0.291	1.222	0.000
4	0.941	0.332	1.273	0.413	1.409	0.177
5	0.912	0.468	1.380	0.528	1.714	0.189
6	0.794	0.700	1.494	0.713	2.647	0.294
7	0.618	0.868	1.486	0.835	4.686	0.440
8	0.382	0.941	1.323	0.866	6.471	0.656
9	0.177	0.986	1.163	0.878	12.941	0.835
10	0.029	1.000	1.029	0.870	—	0.971

LR+: likelihood ratio for a positive test result; LR−: likelihood ratio for a negative test result.
Dataset was retrieved from our previous study [9].
The number of dichotomized variables was the cumulated effects of the various clinicopathologic variables from Table 3, including tumor size, stage, ER, HT, LN metastasis, age, PR, BMI, MRE11 positive cells, and HER2.