Silencing CAPN2 Expression Inhibited Castration-Resistant Prostate Cancer Cells Proliferation and Invasion via AKT/mTOR Signal Pathway

Figure 5

SC79 reversed the inhibitory effects of si-CAPN2 on CRPC cells invasion and proliferation. (a) The proliferation capabilities of DU145 and PC3 cells showed no significant difference between NC and si-CAPN2 + SC79 two groups. (b) SC79 conversed the suppressive effect of si-CAPN2 on CRPC cells invasion abilities. (c) SC79 promoted the protein levels of phosphorylation of AKT/mTOR and MMP-2/9 in si-CAPN2 treated CRPC cells. GAPDH was used as a loading control.

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