Toxicity Studies of Ethyl Maltol and Iron Complexes in Mice

Table 2

Effect of ethyl maltol complexes on male and female mouse organ coefficients ().

Organs	Control group	Test groups
		1/81 LD50	1/27 LD50	1/9 LD50	1/3 LD50
Males
Heart	0.55 ± 0.01	0.55 ± 0.01	0.55 ± 0.01	0.55 ± 0.01	0.55 ± 0.01
Liver	5.33 ± 0.04	5.38 ± 0.03	5.48 ± 0.03	5.74 ± 0.04	5.73 ± 0.03
Spleen	0.46 ± 0.01	0.45 ± 0.01	0.46 ± 0.01	0.46 ± 0.01	0.46 ± 0.01
Lung	0.66 ± 0.01	0.67 ± 0.01	0.67 ± 0.01	0.67 ± 0.01	0.67 ± 0.01
Kidneys	1.46 ± 0.04	1.50 ± 0.02	1.55 ± 0.03	1.72 ± 0.04	1.74 ± 0.03
Females
Heart	0.53 ± 0.01	0.53 ± 0.01	0.53 ± 0.01	0.52 ± 0.01	0.53 ± 0.01
Liver	5.26 ± 0.06	5.25 ± 0.06	5.61 ± 0.22	5.65 ± 0.06	5.75 ± 0.02
Spleen	0.44 ± 0.01	0.44 ± 0.01	0.44 ± 0.01	0.44 ± 0.01	0.44 ± 0.01
Lung	0.62 ± 0.01	0.62 ± 0.01	0.62 ± 0.01	0.62 ± 0.01	0.62 ± 0.01
Kidneys	1.20 ± 0.02	1.22 ± 0.02	1.30 ± 0.01	1.51 ± 0.02	1.50 ± 0.02

Results are expressed as means ± standard deviation (SD). versus the vehicle group.