Toxicity Studies of Ethyl Maltol and Iron Complexes in Mice
Table 3
Haematological parameters of mice after 45-day treatment with ethyl maltol and iron complexes ().
Haematological indices
Control group
Treatment
1/81 LD50
1/27 LD50
1/9 LD50
1/3 LD50
Males
Hb (g L−1)
146.09 ± 2.13
147.09 ± 1.99
152.25 ± 1.10
160.09 ± 0.76
156.97 ± 0.65
RBC (1012 L−1)
8.63 ± 0.22
8.53 ± 0.20
8.45 ± 0.22
9.22 ± 0.09
8.94 ± 0.09
WBC (109 L−1)
7.58 ± 0.31
7.75 ± 0.34
7.49 ± 0.38
8.43 ± 0.17
7.77 ± 0.17
N
28.66 ± 0.41
28.88 ± 0.20
28.84 ± 0.10
29.45 ± 0.18
28.98 ± 0.13
E
2.91 ± 0.08
2.89 ± 0.08
2.95 ± 0.02
2.71 ± 0.07
2.80 ± 0.08
DC (%) B
0.14 ± 0.02
0.18 ± 0.01
0.17 ± 0.01
0.17 ± 0.01
0.17 ± 0.01
M
2.38 ± 0.11
2.39 ± 0.09
2.44 ± 0.08
2.41 ± 0.11
2.61 ± 0.04
L
65.90 ± 0.51
65.66 ± 0.23
65.60 ± 0.11
65.26 ± 0.18
65.43 ± 0.11
Females
Hb (g/L)
131.53 ± 2.2
131.27 ± 2.12
133.92 ± 1.74
139.31 ± 1.30
137.27 ± 1.74
RBC (1012/L)
7.90 ± 0.08
7.85 ± 0.05
8.02 ± 0.05
8.58 ± 0.11
8.18 ± 0.08
WBC (109/L)
5.88 ± 0.071
5.87 ± 0.09
6.00 ± 0.06
6.94 ± 0.06
6.22 ± 0.09
N
27.83 ± 0.52
27.98 ± 0.48
29.71 ± 0.29
33.16 ± 0.49
31.11 ± 0.08
E
3.13 ± 0.03
3.15 ± 0.03
2.99 ± 0.02
2.46 ± 0.07
2.76 ± 0.04
DC (%) B
0.91 ± 0.05
0.93 ± 0.03
0.90 ± 0.04
0.84 ± 0.06
0.91 ± 0.04
M
2.04 ± 0.03
2.06 ± 0.03
2.10 ± 0.03
2.36 ± 0.03
2.15 ± 0.03
L
66.09 ± 0.53
65.89 ± 0.50
64.30 ± 0.31
61.20 ± 0.55
63.06 ± 0.08
The results are expressed as means ± standard deviation (SD). Hb: haemoglobin; RBC: red blood cell; WBC: white blood cell; N: neutrophil; E: eosinophil; B: basophil; M: monocyte; L: lymphocytes. , versus the vehicle group.
