Toxicity Studies of Ethyl Maltol and Iron Complexes in Mice

Table 4

Haematological parameters of mice after 90-day treatment with ethyl maltol and iron complexes ().

Haematological indices	Control group	Treatment
		1/81 LD50	1/27 LD50	1/9 LD50	1/3 LD50
Males
Hb (g L^−1)	158.06 ± 1.03	158.16 ± 0.91	146.31 ± 0.74	124.60 ± 1.93	108.33 ± 3.13
RBC (10^12 L^−1)	10.33 ± 0.34	10.24 ± 0.25	8.37 ± 0.15	7.61 ± 0.15	6.35 ± 0.18
WBC (10^9 L^−1)	8.37 ± 0.23	8.12 ± 0.15	8.43 ± 0.16	10.18 ± 0.26	12.36 ± 0.25
N	28.68 ± 0.27	28.28 ± 0.23	29.20 ± 0.23	32.40 ± 0.37	34.56 ± 0.28
E	2.83 ± 0.05	2.86 ± 0.03	2.75 ± 0.03	2.52 ± 0.03	2.44 ± 0.04
DC (%) B	0.93 ± 0.03	0.93 ± 0.03	0.96 ± 0.03	0.91 ± 0.45	0.93 ± 0.02
M	2.19 ± 0.06	2.20 ± 0.04	2.18 ± 0.05	2.12 ± 0.03	2.15 ± 0.04
L	65.37 ± 0.23	65.73 ± 0.22	64.93 ± 0.23	62.05 ± 0.34	59.91 ± 0.26
Females
Hb (g L^−1)	140.87 ± 0.82	140.53 ± 0.78	134.98 ± 0.48	126.35 ± 1.08	115.56 ± 2.26
RBC (10^12 L^−1)	9.35 ± 0.17	9.71 ± 0.23	8.21 ± 0.18	7.08 ± 0.09	6.19 ± 0.11
WBC (10^9 L^−1)	7.93 ± 0.14	7.91 ± 0.11	8.28 ± 0.07	10.36 ± 0.28	12.34 ± 0.30
N	27.18 ± 0.38	27.50 ± 0.33	29.15 ± 0.32	32.33 ± 0.25	34.14 ± 0.17
E	2.88 ± 0.03	2.86 ± 0.03	2.75 ± 0.04	2.65 ± 0.04	2.42 ± 0.02
DC (%) B	0.97 ± 0.05	0.94 ± 0.02	0.95 ± 0.04	0.94 ± 0.03	0.95 ± 0.04
M	2.23 ± 0.05	2.18 ± 0.03	2.15 ± 0.05	2.11 ± 0.04	2.11 ± 0.03
L	66.73 ± 0.44	66.50 ± 0.31	65.19 ± 0.30	62.06 ± 0.23	60.55 ± 0.13

The results are expressed as means ± standard deviation (SD). versus the vehicle group.