Toxicity Studies of Ethyl Maltol and Iron Complexes in Mice

Table 5

Biochemical parameters of mice of both sexes after 90-day treatment with ethyl maltol and iron complexes ().

Biochemical parameters	Control group	Treatment
		1/81 LD50	1/27 LD50	1/9 LD50	1/3 LD50
Males
TBIL (µmol L^−1)	1.93 ± 0.07	1.95 ± 0.06	2.17 ± 0.05	2.75 ± 0.06	3.04 ± 0.06
ALT (U L^−1)	46.48 ± 2.40	46.16 ± 2.64	63.44 ± 2.45	86.19 ± 2.25	95.34 ± 2.82
ALP (U L^−1)	111.54 ± 3.44	111.38 ± 2.93	96.12 ± 2.10	84.46 ± 2.0	74.42 ± 2.0
AST (U L^−1)	145.23 ± 3.17	146.94 ± 2.85	159.78 ± 2.79	201.86 ± 3.44	236.58 ± 6.13
BUN (mmol L^−1)	10.33 ± 0.31	10.49 ± 0.29	11.78 ± 0.34	14.05 ± 0.47	16.28 ± 0.41
creatinine (μmol L^−1)	13.60 ± 0.28	13.37 ± 0.45	14.88 ± 0.38	18.14 ± 0.38	19.45 ± 0.26
LDH (U L^−1)	889.96 ± 4.48	888.80 ± 4.26	905.53 ± 3.35	970.73 ± 5.41	970.73 ± 5.41
Females
TBIL (µmol L^−1)	1.70 ± 0.02	1.71 ± 0.01	1.80 ± 0.01	1.89 ± 0.02	2.15 ± 0.03
ALT (U L^−1)	44.40 ± 4.21	46.09 ± 1.74	65.38 ± 3.18	71.62 ± 1.69	111.22 ± 4.44
ALP (U L)	143.09 ± 4.01	138.33 ± 2.20	112.14 ± 3.37	98.46 ± 3.62	78.51 ± 3.60
AST (U L^−1)	142.71 ± 3.60	149.90 ± 1.09	178.61 ± 3.47	192.30 ± 1.60	215.21 ± 7.30
BUN (mmol L^−1)	8.42 ± 0.31	8.63 ± 0.30	8.93 ± 0.19	10.64 ± 0.38	12.66 ± 0.25
creatinine (µmol L^−1)	11.16 ± 0.55	11.50 ± 0.49	12.99 ± 0.45	13.84 ± 0.28	14.71 ± 0.31
LDH (U L^−1)	640.69 ± 6.49	637.72 ± 4.78	650.97 ± 4.87	670.83 ± 4.48	660.86 ± 5.15

Results are expressed as means ± standard deviation (SD). versus the vehicle group.