miR-200c Accelerates Hepatic Stellate Cell-Induced Liver Fibrosis via Targeting the FOG2/PI3K Pathway

Figure 4

Schematic model of miR-200c accelerating hepatic stellate cell-induced liver fibrosis via targeting the FOG2/PI3K pathway. miR-200c activates HSCs and finally accelerates the progression of liver fibrosis via downregulation of FOG2 protein synthesis, activation of PI3K/Akt signaling. Autocrine activation of EGF signaling may also be a mechanism of miR-200c-mediated HSCs activation.