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BioMed Research International
Volume 2017, Article ID 2672689, 9 pages
Research Article

Variability of Chemical Compositions and Antimicrobial and Antioxidant Activities of Ruta chalepensis Leaf Essential Oils from Three Palestinian Regions

1Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, P.O. Box 7, Nablus, State of Palestine
2College of Pharmacy, Nursing and Health Professions, Birzeit University, P.O. Box 14, Birzeit, State of Palestine
3Center of Birzeit University Testing Laboratories, Birzeit University, P.O. Box 14, Birzeit, State of Palestine
4Faculty of Agriculture and Veterinary Medicine, An-Najah National University, P.O. Box 7, Nablus, State of Palestine

Correspondence should be addressed to Nidal Jaradat; ude.hajan@tadarajladin

Received 7 July 2017; Revised 5 October 2017; Accepted 19 October 2017; Published 5 November 2017

Academic Editor: Gail B. Mahady

Copyright © 2017 Nidal Jaradat et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. Interest in essential oils was recently revived with their popularity increasing in medicine, pharmacy, and aromatherapy. This study was performed to identify the chemical compositions of the essential oil of Ruta chalepensis growing wildly in three regions in Palestine and to assess and compare their antimicrobial and antioxidant activities. Methods. Identification of the essential oil was performed by gas chromatography coupled with mass spectrometry (GC-MS). Antimicrobial activity was tested against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Methicillin-Resistant Staphylococcus aureus, and Candida albicans by using minimum inhibitory concentration (MIC) assay, while antioxidant activity was analyzed by using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging method. Results. The essential oils of R. chalepensis from Jerusalem and Hebron regions have almost identical components; the major compounds identified were linalyl acetate and β-linalool; these essential oils exerted potential antioxidant and antibacterial activities. On the other hand, the major components of the plant essential oil from Jenin region were 2-undecanone and 2-nonanone, which exhibited potential antifungal activity. Conclusions. The phytoconstituents and antioxidant and antimicrobial properties of the essential oil of R. chalepensis from different regions in Palestine were established in this study. The obtained results indicate possible applications for R. chalepensis in the treatment of various infectious and noninfectious diseases.