Failure of the PTEN/aPKC/Lgl Axis Primes Formation of Adult Brain Tumours in Drosophila

Figure 4

The neoplastic growth induced in type II NBs of the larval brain by the activated form of aPKC leads to formation of adult brain tumours. ((a)–(d)) Representative adult brains from Optix (a), Optix-PI3K (b), (c), and Optix- (d) 1–4-day-old individuals. All the samples are dorsal up and ventral down. While the a-Mira antibody does not stain control (a) and Optix- (b) brains, a myriad Mira-positive cells can be observed both in (c) and in Optix- (d) samples (cyan). Elav and Repo staining is shown in red. (e) Graph displaying the ratio of the total GFP⁺ area normalised to the whole brain area for the two indicated groups. Each triangle represents one brain, and the central bar indicates the average ratio. The two sample groups are not statistically different, . (f) Adult brains from Optix- 1–4-day-old individuals showing PntP1 staining. Scale bars are 50 μm.

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