Table 4: Serum levels of bone turnover markers and bone metabolism proteins.

BaselineFollow-up value

sRANKL (pmol/L)0.32 [0.21–0.67]0.18 [0.11–0.35]
OPG (pmol/L)4.34 [2.60–5.82]4.22 [3.05–5.08]0.7990
sRANKL/OPG0.08 [0.04–0.17]0.05 [0.03–0.07]
DKK1 (pmol/L)25.5 [18.1–43.3]26.4 [21.9–31.7]1.000
Sclerostin (pmol/L)25.2 [16.94–33.8]25.2 [19.2–29.3]0.8577
CTX-I (ng/mL)194.6 [176.6–430.7]163.6 [152.1–173.9]
P1NP (ng/mL)55.7 [46.3–61.3]45.8 [39.6–48.9]
CTX/P1NP3.36 [3.09–3.82]3.71 [3.34–4.30]0.5590

Enzyme-linked immunosorbent assay results are shown as median and interquartile range. sRANKL: soluble receptor activator of NF-κβ ligand; OPG: osteoprotegerin; DKK1: Dickkopf-related protein-1: CTX: carboxyterminal telopeptide of type I collagen; P1NP: total procollagen type 1 N-terminal propeptide; , , and . Remained significant after correction for multiple comparisons.