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| Intervention | Ref | Study design | Sample size | Hyperacusis complaint | Aimed at treating hy | Outcome measures | Main findings |
| Primary | Secondary |
|
| Pharmacological | Nields et al. [50] | Case report | 1 | Within symptom set | No | Self-report | Not stated | Intravenous ceftriaxone led to a remission of all symptoms, but hyperacusis worsened afterwards. Intravenous cefotaxim diminished hyperacusis but did not completely abate it. Hyperacusis fluctuated. Clonazepam led to short-term attenuation of hyperacusis but increased emotional liability. Threshold for sound tolerance increased and sounds no longer seemed to “add up” following carbamazepine and patient reported increased ability to recover more quickly. |
| Pharmacological | Gopal et al. [51] | Case report | 1 | Within symptom set | No | (1) pure-tone threshold testing (250–8000 Hz), (2) impedance testing (tympanograms and acoustic reflex thresholds), (3) speech audiometry (speech threshold, word recognition score), (4) click evoked ABR testing, (5) transient evoked otoacoustic emission (TEOAE) testing, (6) uncomfortable loudness level (LDL) testing, (7) a screening test for central auditory processing disorders (SCAN-A testing), and (8) blood serum serotonin level | No remarkable clinical differences were reported by the patient between the unmedicated and medicated (fluvoxamine and fluoxetine) conditions for (1) pure-tone thresholds, (2) speech thresholds, (3) word recognition scores, or (4) tympanograms and (5) acoustic reflex thresholds. Only (6) LDLs were different between the two conditions, with the medicated condition showing increased sound tolerance. |
| Pharmacological | Brookler [52] | Case report | 1 | Within symptom set | No | Self-report | Not stated | Patient self-reported that following the diet regime made her feel better. |
| Pharmacological | Lee et al. [53] | Case report | 1 | Within symptom set | No | Self-report | Not stated | Hyperacusis and tinnitus persisted but intensity reduced after 1 month of treatment. |
| Pharmacological | Brookler [54] | Case report | 1 | Within Symptom set | No | Self-report | Not stated | The patient initially reported that hyperacusis was worse on risedronate. Following changes to the regime to risedronate, hyperacusis was less frequent and almost gone, although tinnitus and aural fullness remained present. |
| Surgery | Khalil et al. [55] | Case report | 1 | Primary | No | Self-report | Not stated | Hyperacusis completely resolved after procedure and had not returned after 10 months. |
| Surgery | Nikkar-Esfahani et al. [56] | Case series | 2 | Primary | Yes | Self-report | Not stated | Patients reported postoperative improvement in symptoms. Two years after the procedure, symptoms had continued to improve, with no significant problems. |
| Surgery | Dang et al. [57] | Case report | 1 | Primary | Yes | Self-report | Not stated | The patient self-reported that right-sided hyperacusis significantly improved at 1 month postop and completely resolved at 3 months postop. The patient was able to resume all choir-related activities. |
| Surgery | Silverstein et al. [58] | Case series | 2 | Within symptom set | Yes | HQ | LDLs (only postop data) | The patient reported marked improvement of hyperacusis and quality of life, with a decrease in hyperacusis survey scores and LDLs above 90 dB |
| Surgery | J. Gavilán and C. Gavilán [59] | Cohort | 59 | Within symptom set | No | Self-report | Not stated | In the majority of cases (63% = 37 cases), hyperacusis improved or disappeared following surgery. Only in two cases did hyperacusis become more severe, ten years after surgery. |
| Surgery | Silverstein et al. [60] | Cohort | 6 | Primary | Yes | Hyperacusis Questionnaire adapted from GÜF and LDLs | Not specified | All unilateral patients and two of the three bilateral patients reported subjective improvement in sound hypersensitivity, with reduced questionnaire scores and improved LDLs following treatment. The patients reported no change in hearing and improved quality of life after the procedure; one reported improved noise tolerance in social situations. |
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