BioMed Research International / 2017 / Article / Tab 1

Research Article

Genetic Variants in the Hedgehog Interacting Protein Gene Are Associated with the FEV1/FVC Ratio in Southern Han Chinese Subjects with Chronic Obstructive Pulmonary Disease

Table 1

Demographic characteristics in COPD patients and controls.

VariablesStudy ΙStudy ΙΙCombined
CasesControlsCasesControlsCaseControl
()()()()()()
± sd± sd± sd± sd± sd &± sd
(%) (%) (%) (%) (%) (%)

Age (years)60.2 ± 9.960.6 ± 7.50.59762.2 ± 9.561.3 ± 8.60.1620.20161.0 ± 9.760.9 ± 8.50.807
Gender, male (%)516 (86.8)497 (82.9)0.186339 (85.8)208 (52.1)<0.001<0.001855 (86.4)705 (70.6)<0.001
FEV1 (L)0.98 ± 0.542.43 ± 0.56<0.0010.92 ± 0.372.47 ± 0.54<0.0010.0510.96 ± 0.372.44 ± 0.55<0.001
FEV1 predict pre- (%)42.2 ± 20.594.3 ± 15.7<0.00141.8 ± 18.395.7 ± 14.6<0.0010.22142.1 ± 18.294.8 ± 15.3<0.001
FEV1/FVC (%)46.9 ± 17.781.4 ± 6.8<0.00146.7 ± 16.981.7 ± 6.4<0.0010.53646.8 ± 16.981.5 ± 6.7<0.001
Pack-years42.1 ± 27.616.9 ± 13.3<0.00135.6 ± 20.910.8 ± 4.9<0.0010.00139.4 ± 19.514.4 ± 8.6<0.001
Smoking status<0.001<0.0010.092<0.001
 Smoker74 (12.5)179 (29.9)45 (11.4)118 (9.6)119 (12.0)297 (29.7)
 Ex-smoker421 (70.9)6 (1.0)282 (71.4)3 (0.8)703 (71.1)9 (0.9)
 Nonsmoker99 (16.6)415 (69.1)68 (17.2)278 (9.6)167 (16.9)693 (69.4)
GLI0.479
 Mild89 (15.0)66 (16.7)155 (15.7)
 Moderate94 (15.8)62 (15.7)156 (15.8)
 Moderately severe224 (37.7)144 (36.5)368 (37.2)
 Severe187 (31.5)123 (31.1)310 (31.3)

values for a two-sided test or -test; values for the test of homogeneity by Breslow-Day test or test; FEV1: forced expiratory volume in 1 second; -BD: prebronchodilator; FVC: forced vital capacity; in bold is .

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