Genetic Variants in the Hedgehog Interacting Protein Gene Are Associated with the FEV1/FVC Ratio in Southern Han Chinese Subjects with Chronic Obstructive Pulmonary Disease
Table 2
Genetic association results in the case-control study (left column) and associations with FEV1 and the FEV1/FVC% in the subjects with COPD (right column).
SNP
Gene
Chr
Minor
Logistic regression
Linear regression in COPD (crude)
Linear regression in COPD (adjusted)
MAF
FEV1
FEV1/FVC%
FEV1
FEV1/FVC%
Allele
COPD
Control
β
P
β
P
β
β
Combined population (number of COPD = 989, control = 999)
rs1903003
FAM13A
4
88965146
C
0.23
0.430
0.467
0.05
0.008
0.628
0.59
0.31
0.01
0.85
0.64
0.41
—
rs2869967
FAM13A
4
88948181
T
0.21
0.468
0.519
0.03
−0.01
0.415
0.48
0.39
−0.02
0.47
0.52
0.50
—
rs7671167
FAM13A
4
88962828
C
0.72
0.455
0.487
0.11
−0.44
0.597
0.35
0.55
−0.01
0.58
0.34
0.66
—
rs12504628
HHIP
4
144515172
C
0.56
0.242
0.262
0.37
2.33
0.017
3.45
1.32e−4
0.06
0.07
2.01
0.01
—
rs1512281
HHIP
4
144513749
G
0.50
0.244
0.264
0.36
2.28
0.018
3.42
1.33e−4
0.06
0.09
1.95
0.02
—
rs12509311
HHIP
4
144557510
T
0.99
0.229
0.251
0.27
2.66
0.007
4.26
2.72e−6
0.05
0.12
2.68
4.1e−4
0.95
rs13118928
HHIP
4
144565237
G
0.95
0.230
0.253
0.23
2.60
0.008
4.19
3.87e−6
0.06
0.09
2.74
2.8e−4
0.96
rs1828591
HHIP
4
144559628
G
0.99
0.229
0.251
0.27
2.66
0.007
4.26
2.72e−6
0.05
0.12
2.68
4.1e−4
0.95
version of chromosome location is GRCh38 in GenBank of PubMed Centre; : calculated by the Hardy-Weinberg equilibrium among the control subjects. in a logistic or linear regression model that included gender, age, and pack-years of smoking. powers: measured by linear regression in the FEV1/FVC%. Minimum call rate of the alleles is 99.33%. In bold is .
