BioMed Research International / 2017 / Article / Tab 2

Research Article

Genetic Variants in the Hedgehog Interacting Protein Gene Are Associated with the FEV1/FVC Ratio in Southern Han Chinese Subjects with Chronic Obstructive Pulmonary Disease

Table 2

Genetic association results in the case-control study (left column) and associations with FEV1 and the FEV1/FVC% in the subjects with COPD (right column).

SNPGeneChrMinorLogistic regression Linear regression in COPD (crude) Linear regression in COPD (adjusted)
MAFFEV1 FEV1/FVC%FEV1 FEV1/FVC%
AlleleCOPDControlβPβPββ

Combined population (number of COPD = 989, control = 999)
rs1903003FAM13A488965146C0.230.4300.4670.050.0080.6280.590.310.010.850.640.41
rs2869967FAM13A488948181T0.210.4680.5190.03−0.010.4150.480.39−0.020.470.520.50
rs7671167FAM13A488962828C0.720.4550.4870.11−0.440.5970.350.55−0.010.580.340.66
rs12504628HHIP4144515172C0.560.2420.2620.372.330.0173.451.32e40.060.072.010.01
rs1512281HHIP4144513749G0.500.2440.2640.362.280.0183.421.33e40.060.091.950.02
rs12509311HHIP4144557510T0.990.2290.2510.272.660.0074.262.72e60.050.122.684.1e40.95
rs13118928HHIP4144565237G0.950.2300.2530.232.600.0084.193.87e60.060.092.742.8e40.96
rs1828591HHIP4144559628G0.990.2290.2510.272.660.0074.262.72e60.050.122.684.1e40.95

version of chromosome location is GRCh38 in GenBank of PubMed Centre; : calculated by the Hardy-Weinberg equilibrium among the control subjects. in a logistic or linear regression model that included gender, age, and pack-years of smoking. powers: measured by linear regression in the FEV1/FVC%. Minimum call rate of the alleles is 99.33%. In bold is .

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