Genetic Variants in the Hedgehog Interacting Protein Gene Are Associated with the FEV1/FVC Ratio in Southern Han Chinese Subjects with Chronic Obstructive Pulmonary Disease
Table 3
Analyses of associations between 3 SNPs in the HHIP gene and COPD.
Genotypes/alleles
Case
Control
Crude
Adjusted
(%)
(%)
OR (95% CI)
OR (95% CI)
Total number of subjects
989
999
Total number of alleles
1978
1998
rs12509311C>T
Codominant model
CC
581 (59.0)
559 (56.1)
1.00 (ref.)
1.00 (ref.)
CT
356 (36.1)
374 (37.6)
0.92 (0.76–1.10)
0.85 (0.62–1.17)
0.32
TT
48 (4.9)
63 (6.3)
0.73 (0.50–1.09)
0.69 (0.38–1.27)
0.24
Additive model
0.89 (0.77–1.03)
0.84 (0.66–1.07)
0.16
Dominant model
CT + TT
404 (41.0)
437 (43.9)
0.89 (0.74–1.06)
0.82 (0.61–1.11)
0.21
Recessive model
CC + CT
937 (95.1)
933 (93.7)
1.00 (ref.)
1.00 (ref.)
TT
48 (4.9)
63 (6.3)
0.76 (0.52–1.12)
0.74 (0.41–1.33)
0.31
rs13118928A>G
Codominant model
AA
581 (58.9)
559 (56.0)
1.00 (ref.)
1.00 (ref.)
GA
358 (36.3)
374 (37.4)
0.92 (0.77–1.11)
0.85 (0.62–1.17)
0.33
GG
48 (4.8)
66 (6.6)
0.70 (0.47–1.03)
0.69 (0.38–1.25)
0.22
Additive model
0.88 (0.76–1.02)
0.84 (0.66–1.07)
0.15
Dominant model
GA + GG
406 (41.1)
440 (44.0)
0.89 (0.74–1.06)
0.82 (0.61–1.11)
0.20
Recessive model
AA + GA
939 (95.2)
933 (93.4)
1.00 (ref.)
1.00 (ref.)
GG
48 (4.8)
66 (6.6)
0.72 (0.49–1.06)
0.73 (0.40–1.31)
0.29
rs1828591A>G
Codominant model
AA
581 (59.0)
559 (56.1)
1.00 (ref.)
1.00 (ref.)
GA
356 (36.1)
374 (37.6)
0.92 (0.76–1.10)
0.85 (0.62–1.17)
0.32
GG
48 (4.9)
63 (6.3)
0.73 (0.50–1.09)
0.69 (0.38–1.27)
0.24
Additive model
0.89 (0.77–1.03)
0.84 (0.66–1.07)
0.16
Dominant model
GA + GG
404 (41.0)
437 (43.9)
0.89 (0.74–1.06)
0.82 (0.61–1.11)
0.21
Recessive model
AA + GA
937 (95.1)
933 (93.7)
1.00 (ref.)
1.00 (ref.)
GG
48 (4.9)
63 (6.3)
0.76 (0.52–1.12)
0.74 (0.41–1.33)
0.31
in a logistic regression model that included gender, age, and pack-years of smoking.
