BioMed Research International / 2017 / Article / Tab 3

Research Article

Genetic Variants in the Hedgehog Interacting Protein Gene Are Associated with the FEV1/FVC Ratio in Southern Han Chinese Subjects with Chronic Obstructive Pulmonary Disease

Table 3

Analyses of associations between 3 SNPs in the HHIP gene and COPD.

Genotypes/allelesCaseControlCrudeAdjusted
(%) (%)OR (95% CI)OR (95% CI)

Total number of subjects989999
Total number of alleles19781998
rs12509311C>T
Codominant model
 CC581 (59.0)559 (56.1)1.00 (ref.)1.00 (ref.)
 CT356 (36.1)374 (37.6)0.92 (0.76–1.10)0.85 (0.62–1.17)0.32
 TT48 (4.9)63 (6.3)0.73 (0.50–1.09)0.69 (0.38–1.27)0.24
Additive model0.89 (0.77–1.03)0.84 (0.66–1.07)0.16
Dominant model
 CT + TT404 (41.0)437 (43.9)0.89 (0.74–1.06)0.82 (0.61–1.11)0.21
Recessive model
 CC + CT937 (95.1)933 (93.7)1.00 (ref.)1.00 (ref.)
 TT48 (4.9)63 (6.3)0.76 (0.52–1.12)0.74 (0.41–1.33)0.31
rs13118928A>G
Codominant model
 AA581 (58.9)559 (56.0)1.00 (ref.)1.00 (ref.)
 GA358 (36.3)374 (37.4)0.92 (0.77–1.11)0.85 (0.62–1.17)0.33
 GG48 (4.8)66 (6.6)0.70 (0.47–1.03)0.69 (0.38–1.25)0.22
Additive model0.88 (0.76–1.02)0.84 (0.66–1.07)0.15
Dominant model
 GA + GG406 (41.1)440 (44.0)0.89 (0.74–1.06)0.82 (0.61–1.11)0.20
Recessive model
 AA + GA939 (95.2)933 (93.4)1.00 (ref.)1.00 (ref.)
 GG48 (4.8)66 (6.6)0.72 (0.49–1.06)0.73 (0.40–1.31)0.29
rs1828591A>G
Codominant model
 AA581 (59.0)559 (56.1)1.00 (ref.)1.00 (ref.)
 GA356 (36.1)374 (37.6)0.92 (0.76–1.10)0.85 (0.62–1.17)0.32
 GG48 (4.9)63 (6.3)0.73 (0.50–1.09)0.69 (0.38–1.27)0.24
Additive model0.89 (0.77–1.03)0.84 (0.66–1.07)0.16
Dominant model
 GA + GG404 (41.0)437 (43.9)0.89 (0.74–1.06)0.82 (0.61–1.11)0.21
Recessive model
 AA + GA937 (95.1)933 (93.7)1.00 (ref.)1.00 (ref.)
 GG48 (4.9)63 (6.3)0.76 (0.52–1.12)0.74 (0.41–1.33)0.31

in a logistic regression model that included gender, age, and pack-years of smoking.

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