BioMed Research International / 2017 / Article / Tab 4

Research Article

Genetic Variants in the Hedgehog Interacting Protein Gene Are Associated with the FEV1/FVC Ratio in Southern Han Chinese Subjects with Chronic Obstructive Pulmonary Disease

Table 4

Linear regression analyses of the genetic associations among SNP and lung function, COPD severity, and smoking amount in the subjects with COPD.

Subjects with COPD ()
FEV1FEV1 pre-BDThe FEV1/FVC%GOLDPack-yearsSmoking status
β (SE)β (SE)β (SE)β (SE)β (SE)β (SE)

rs125093110.052 (0.033)0.1220.041 (0.025)0.1052.683 (0.757)4.1e4−0.020 (0.044)0.6441.317 (1.257)0.153−0.030 (0.026)0.251
rs131189280.057 (0.033)0.0890.040 (0.025)0.1082.743 (0.754)2.8e4−0.027 (0.044)0.5381.392 (1.257)0.145−0.036 (0.026)0.172
rs18285910.052 (0.033)0.1220.041 (0.025)0.1052.683 (0.757)4.1e4−0.020 (0.044)0.6441.317 (1.257)0.153−0.030 (0.026)0.251

with adjusting gender, age, and pack-years of smoking in linear regression. Statistical powers are 0.85, 0.86, and 0.85 for rs12509311, rs13118928, and rs1828591 in the FEV1/FVC%, respectively. The data presented are β (SE) with two-sided value. FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; in bold is .

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