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BioMed Research International
Volume 2017 (2017), Article ID 2759035, 8 pages
https://doi.org/10.1155/2017/2759035
Research Article

Quantitative Changes in Cerebral Perfusion during Urinary Urgency in Women with Overactive Bladder

1Department of Obstetrics and Gynecology, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA, USA
2Department of Urology, Stony Brook School of Medicine, Stony Brook, NY, USA
3Center for Functional Neuroimaging, Department of Neurology, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA, USA

Correspondence should be addressed to Nisha G. Arya; moc.liamg@0002ahsinayra

Received 18 May 2017; Accepted 16 July 2017; Published 17 August 2017

Academic Editor: Nader Pouratian

Copyright © 2017 Nisha G. Arya et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. To quantitatively measure changes in cerebral perfusion in select regions of interest in the brain during urinary urgency in women with overactive bladder (OAB) using arterial spin labeling (ASL). Methods. Twelve women with OAB and 10 controls underwent bladder filling and rated urinary urgency (scale 0–10). ASL fMRI scans were performed (1) in the low urgency state after voiding and (2) high urgency state after drinking oral fluids. Absolute regional cerebral blood flow (rCBF) in select regions of interest was compared between the low and high urgency states. Results. There were no significant differences in rCBF between the low and high urgency states in the control group. In the OAB group, rCBF (mean ± SE, ml/100 g/min) increased by 10–14% from the low to the high urgency state in the right anterior cingulate cortex (ACC) ( versus , ), left ACC ( versus , ), and left insula ( versus , ). Whole-brain analysis identified additional areas of activation in the right insula, right dorsolateral prefrontal cortex, and pons/midbrain area. Conclusions. Urinary urgency is associated with quantitative increase in cerebral perfusion in regions of the brain associated with processing emotional response to discomfort.