Screening of Tumor Suppressor Genes in Metastatic Colorectal Cancer

Table 1

The distribution of clinical characteristics of methylation and expression profile in CRC patients.

Characteristics	Colorectal cancer
	Methylation	Expression
Sum	166	155
Gender
Male	83	79
Female	83	76
Age at initial pathologic diagnosis
<50	12	10
≥50	154	145
Anatomic neoplasm subdivision
Ascending colon	32	28
Cecum	33	29
Descending colon	6	6
Hepatic flexure	8	9
Sigmoid colon	69	66
Splenic flexure	2	2
Transverse colon	15	14
TNM
T1 + T2 + T3 + T4	166	155
N1 + N2	67	60
M1	24	23
AJCC pathologic tumor_stage
Stage I	32	29
Stage II	64	63
Stage III	45	39
Stage IV	24	23
Histologic diagnosis
Colon adenocarcinoma	140	131
Colon mucinous adenocarcinoma	24	22
Family history colorectal cancer
Yes	26	23
No	140	132
History of another malignancy
Yes	9	9
No	157	146
History colon polyps
Yes	85	84
No	81	71
Tumor status
Tumor free	10	10
With tumor	155	144
Vascular invasion indicator
Yes	37	34
No	106	107
Lymphovascular invasion indicator
Yes	87	78
No	70	72