BioMed Research International

Research Article

Bioinformatics Analysis Reveals MicroRNAs Regulating Biological Pathways in Exercise-Induced Cardiac Physiological Hypertrophy

Table 3

The KEGG pathways incorporated by upregulated miRNAs.
KEGG pathway−log( value)Genes
ECM-receptor interaction55.86Col2a1, Col3a1, Col6a3, Col1a1, Col4a4, Col5a2, Col5a3, Col4a1, Col4a3, Col11a1, Col4a2, Col5a1
Fatty acid degradation16.12Hadha, Ehhadh, Acadm
Fatty acid metabolism9.93Hadha, Ehhadh, Acadm
Amoebiasis6.21Col2a1, Col3a1, Col1a1, Prkx, Col4a4, Col5a2, Col5a3, Col4a1, Col4a3, Col11a1, Col4a2, Col5a1
Fatty acid elongation4.85Hadha
Protein digestion and absorption3.93Col2a1, Col3a1, Col6a3, Col1a1, Col4a4, Col5a2, Col5a3, Col9a1, Col4a1, Col4a3, Col11a1, Atp1b4, Col4a2, Col5a1
PI3K-Akt signaling pathway2.81Tsc1.Col2a1.Col3a1.Ddit4.Fgf.Col6a3.Lpar6.Fgf12.Eif4b.Col1a1.Irs1.Them4.Vegfa. Egfr.Ppp2ca.Ghr.Col4a.Tek.Col5a2.Osmr.Ppp2cb.Col5a.Ppp2r3c.Gng5.Col4a1. Col4a.Col11a1.Myb.Gnb3.Col4a.Col5a1.Kit
Tyrosine metabolism2.36Maoa, ldh1a3
Other types of O-glycan biosynthesis2.23Pomt2, Fut9, Colgalt2
Glycosphingolipid biosynthesis-lacto and neolacto series1.81B3galt2, Fut9
Valine, leucine and isoleucine degradation1.81Hadha, Ehhadh, Acadm
Focal adhesion1.41Col2a1.Col3a1.Vav3.Col6a3.Col1a1.Vegfa.Crkl.Egfr.Col4a.Col5a2.Col5a3.Mylk. Col4a1.Col4a3.Col11a1.Col4a2.Col5a1.Ppp1ccsee interacti