Positive Association between ANKRD55 Polymorphism 7731626 and Dermatomyositis/Polymyositis with Interstitial Lung Disease in Chinese Han Population
Table 4
Analysis of the five SNPs based on additive, dominant, and recessive model.
Gene
SNP
Allele
Group
Additive model
Dominant model
Recessive model
Pc
OR (95% CI)
Pc
OR (95% CI)
Pc
OR (95% CI)
TNFSF4
rs2205960
T
DM
NS
1.00 (0.86–1.17)
NS
0.98 (0.81–1.18)
NS
1.09 (0.74–1.59)
PM
NS
1.04 (0.86–1.26)
NS
1.08 (0.86–1.36)
NS
1.09 (0.74–1.59)
DM/PM
NS
1.02 (0.89–1.16)
NS
1.01 (0.86–1.20)
NS
1.04 (0.74–1.46)
TNFSF4
rs844644
C
DM
0.830
1.10 (0.96–1.26)
0.385
1.21 (0.98–1.48)
NS
1.05 (0.83–1.33)
PM
NS
1.05 (0.89–1.24)
NS
1.14 (0.89–1.48)
NS
1.05 (0.83–1.33)
DM/PM
0.965
1.08 (0.96–1.22)
0.340
1.18 (0.99–1.42)
NS
1.02 (0.83–1.26)
TNFSF4
rs844648
A
DM
NS
1.08 (0.94–1.23)
0.205
1.24 (1.01–1.53)
NS
0.95 (0.75–1.20)
PM
NS
1.05 (0.89–1.24)
0.655
1.22 (0.94–1.58)
NS
0.95 (0.75–1.20)
DM/PM
NS
1.07 (0.95–1.20)
0.115
1.24 (1.03–1.48)
NS
0.93 (0.76–1.14)
ANKRD55
rs6859219
A
DM
NS
0.75 (0.27–2.12)
NS
0.75 (0.27–2.12)
NA
NA
PM
NS
1.36 (0.48–3.84)
NS
1.36 (0.48–3.84)
NA
NA
DM/PM
NS
0.97 (0.42–2.22)
NS
0.97 (0.42–2.22)
NA
NA
ANKRD55
rs7731626
A
DM
0.135
0.76 (0.60–0.97)
0.155
0.75 (0.58–0.97)
NS
0.61 (0.22–1.67)
PM
0.760
0.81 (0.60–1.08)
NS
0.83 (0.61–1.14)
0.700
0.61 (0.22–1.67)
DM/PM
0.085
0.78 (0.63–0.96)
0.145
0.78 (0.62–0.97)
0.575
0.47 (0.18–1.20)
SNPs = single nucleotide polymorphisms; Pc = value corrected by Bonferroni method; OR = odds ratio; CI = confidence interval; DM = dermatomyositis; PM = polymyositis; NS = not significant; NA = not available.
