Research Article

The Effect of Botulinum Toxin Type A on Expression Profiling of Long Noncoding RNAs in Human Dermal Fibroblasts

Figure 3

The differential expression levels of message RNAs (mRNAs) between control and BoNTA (5 U/106 cells 48 h) treated groups of microarray results were validated by qRT-PCR. Nine mRNAs (FCN2, SPINT1, PLAC, BIRC5, E2F1, COL19A1, FOS, NOS2, and C13orf15) were studied using glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as an internal control. The heights of the columns in the chart represent the fold changes. Data are the mean ± SEM (). was considered to indicate a statistically significant difference compared with control HDFs. , , and .