Transient Receptor Potential Melastatin 2 Negatively Regulates LPS-ATP-Induced Caspase-1-Dependent Pyroptosis of Bone Marrow-Derived Macrophage by Modulating ROS Production

Figure 3

In TRPM2−/− mice, the activation of caspase-1 and caspase-1-dependent pyroptosis was inhibited by NAC treatment or DPI treatment. means that this group compared to LPS + ATP group in the same type mice. means that TRPM2−/− group compared to WT group. In TRPM2−/− mice, the activation of caspase-1 was reduced in LPS + NAC + ATP group and LPS + DPI + ATP group compared to LPS + ATP group.

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