Transient Receptor Potential Melastatin 2 Negatively Regulates LPS-ATP-Induced Caspase-1-Dependent Pyroptosis of Bone Marrow-Derived Macrophage by Modulating ROS Production

Figure 4

ASC oligomerization was largely increased in TRPM2−/− group compared to WT group. ASC oligomerization was significantly higher in TRPM2−/− group compared to WT group. And in both TRPM2−/− group and WT group, ASC oligomerization was inhibited by NAC or DPI treatment.