Association between Nicotinamide N-Methyltransferase Gene Polymorphisms and Obesity in Chinese Han Male College Students
Table 1
The distribution of alleles and genotypes of the 19 tag SNPs.
SNPs
Allele frequency
Genotype frequency
HWE
rs2511153
Case
C: 352 (0.63)
T: 206 (0.37)
0.708
CC: 108 (0.39)
CT: 57 (0.44)
TT: 20 (0.16)
0.827
Ctrl.
C: 625 (0.64)
T: 351 (0.36)
CC: 199 (0.41)
CT: 227 (0.47)
TT: 62 (0.13)
0.83
rs505978
Case
A: 307 (0.54)
C: 261 (0.46)
0.668
AA: 80 (0.28)
AC: 254 (0.52)
CC: 57 (0.20)
0.909
Ctrl.
A: 544 (0.55)
C: 442 (0.45)
AA: 145 (0.29)
AC: 66 (0.50)
CC: 94 (0.19)
0.36
rs694539
Case
A: 192 (0.34)
G: 374 (0.66)
0.613
AA: 30 (0.11)
AG: 132 (0.47)
GG: 121 (0.43)
0.861
Ctrl.
A: 347 (0.35)
G: 639 (0.65)
AA: 55 (0.11)
AG: 237 (0.48)
GG: 201 (0.41)
0.23
rs12285641
Case
C: 349 (0.62)
T: 217 (0.38)
0.817
CC: 102 (0.36)
CT: 145 (0.51)
TT: 36 (0.13)
0.820
Ctrl.
C: 585 (0.61)
T: 373 (0.39)
CC: 174 (0.36)
CT: 237 (0.50)
TT: 68 (0.14)
0.38
rs11214926
Case
A: 154 (0.27)
G: 410 (0.73)
0.871
AA: 18 (0.06)
AG: 118 (0.42)
GG: 146 (0.52)
0.810
Ctrl.
A: 273 (0.28)
G: 713 (0.72)
AA: 28 (0.06)
AG: 217 (0.44)
GG: 248 (0.50)
0.03
rs7109984
Case
C: 502 (0.89)
T: 64 (0.11)
0.221
CC: 224 (0.79)
CT: 54 (0.19)
TT: 5 (0.02)
0.407
Ctrl.
C: 829 (0.87)
T: 129 (0.14)
CC: 359 (0.75)
CT: 111 (0.23)
TT: 9 (0.02)
0.90
rs10891644
Case
G: 370 (0.64)
T: 206 (0.36)
GG: 111 (0.39)
GT: 148 (0.51)
TT: 29 (0.10)
Ctrl.
G: 674 (0.70)
T: 294 (0.30)
GG: 243 (0.50)
GT: 188 (0.39)
TT: 53 (0.11)
0.07
rs55675450
Case
A: 88 (0.16)
G: 470 (0.84)
0.368
AA: 5 (0.02)
AG: 78 (0.28)
GG: 196 (0.70)
0.056
Ctrl.
A: 138 (0.14)
G: 842 (0.86)
AA: 17 (0.04)
AG: 104 (0.21)
GG: 369 (0.75)
0.01
rs2244175
Case
A: 274 (0.48)
G: 292 (0.52)
0.147
AA: 64 (0.23)
AG: 146 (0.52)
GG: 73 (0.26)
0.337
Ctrl.
A: 515 (0.52)
G: 471 (0.48)
AA: 132 (0.27)
AG: 251 (0.51)
GG: 110 (0.22)
0.65
rs2847492
Case
A: 198 (0.35)
G: 368 (0.65)
0.162
AA: 33 (0.12)
AG: 132 (0.47)
GG: 118 (0.42)
0.366
Ctrl.
A: 380 (0.39)
G: 606 (0.62)
AA: 72 (0.15)
AG: 236 (0.48)
GG: 185 (0.38)
0.82
rs2852432
Case
C: 336 (0.59)
T: 232 (0.41)
0.209
CC: 94 (0.33)
CT: 148 (0.52)
TT: 42 (0.15)
0.286
Ctrl.
C: 551 (0.56)
T: 435 (0.44)
CC: 153 (0.31)
CT: 245 (0.50)
TT: 95 (0.19)
0.86
rs4646335
Case
A: 326 (0.57)
T: 242 (0.43)
0.387
AA: 89 (0.31)
AT: 148 (0.52)
TT: 47 (0.17)
0.666
Ctrl.
A: 588 (0.60)
T: 398 (0.40)
AA: 169 (0.34)
AT: 250 (0.51)
TT: 74 (0.15)
0.24
rs3819100
Case
A: 282 (0.50)
G: 284 (0.50)
0.597
AA: 70 (0.25)
AG: 142 (0.50)
GG: 71 (0.25)
0.825
Ctrl.
A: 505 (0.51)
G: 481 (0.49)
AA: 126 (0.26)
AG: 253 (0.51)
GG: 114 (0.23)
0.55
rs2256292
Case
C: 234 (0.41)
G: 338 (0.59)
0.417
CC: 50 (0.18)
CG: 134 (0.47)
GG: 102 (0.36)
0.526
Ctrl.
C: 382 (0.39)
G: 602 (0.61)
CC: 71 (0.14)
CG: 240 (0.49)
GG: 181 (0.37)
0.55
rs2301128
Case
A: 81 (0.15)
G: 477 (0.86)
0.071
AA: 3 (0.01)
AG: 75 (0.27)
GG: 201 (0.72)
0.051
Ctrl.
A: 111 (0.11)
G: 867 (0.89)
AA: 8 (0.02)
AG: 95 (0.19)
GG: 386 (0.79)
0.44
rs1941404
Case
C: 265 (0.47)
T: 301 (0.53)
0.472
CC: 59 (0.21)
CT: 147 (0.52)
TT: 77 (0.27)
0.762
Ctrl.
C: 443 (0.45)
T: 543 (0.55)
CC: 94 (0.19)
CT: 255 (0.52)
TT: 144 (0.29)
0.32
rs2155806
Case
C: 59 (0.11)
T: 499 (0.89)
0.200
CC: 1 (0.00)
CT: 57 (0.20)
TT: 221 (0.79)
0.387
Ctrl.
C: 125 (0.13)
T: 853 (0.87)
CC: 4 (0.01)
CT: 117 (0.24)
TT: 368 (0.75)
0.11
rs1941399
Case
A: 102 (0.18)
C: 464 (0.82)
0.425
AA: 4 (0.01)
AC: 94 (0.33)
CC: 185 (0.65)
0.152
Ctrl.
A: 194 (0.20)
C: 792 (0.80)
AA: 19 (0.04)
AC: 156 (0.32)
CC: 318 (0.65)
0.98
rs4646337
Case
A: 479 (0.86)
G: 79 (0.14)
0.935
AA: 201 (0.72)
AG: 77 (0.28)
GG: 1 (0.00)
0.102
Ctrl.
A: 841 (0.86)
G: 137 (0.14)
AA: 362 (0.74)
AG: 117 (0.24)
GG: 10 (0.02)
0.88
HWE, Hardy–Weinberg equilibrium; Case, the high body fat group; Ctrl., the low body fat group. HWE, value of Hardy–Weinberg equilibrium test on the control group; the values of allele and genotype are the number of individuals (frequency); ; .
