Research Article
Parental Genetic Variants, MTHFR 677C>T and MTRR 66A>G, Associated Differently with Fetal Congenital Heart Defect
Table 3
Distribution of MTHFR 677C>T, MTHFR 1298A>C, and MTRR 66A>G polymorphisms.
| | | | Control (114) | Non-VSD (78) | VSD (21) | | Mother | Father | | | Mother | Father | | | Mother | Father | | |
| | MTHFR 677C>T | C | 120 (52.6) | 121 (53.1) | 0.009 | 0.925 | 57 (36.5) | 63 (40.4) | 0.488 | 0.485 | 24 (57.1) | 25 (59.5) | 0.049 | 0.825 | | T | 108 (47.4) | 107 (46.9) | | | 99 (63.5) | 93 (59.6) | | | 18 (42.9) | 17 (40.5) | | | | MTHFR 1298A>C | A | 202 (88.6) | 195 (85.5) | 0.954 | 0.329 | 135 (86.5) | 131 (84.0) | 0.408 | 0.523 | 35 (83.3) | 36 (85.7) | 0.091 | 0.763 | | C | 26 (11.4) | 33 (14.5) | | | 21 (13.5) | 25 (16.0) | | | 7 (16.7) | 6 (14.3) | | | | MTRR 66A>G | A | 178 (78.1) | 180 (78.9) | 0.052 | 0.820 | 109 (69.9) | 119 (76.3) | 1.629 | 0.202 | 25 (59.5) | 26 (61.9) | 0.050 | 0.823 | | G | 50 (21.9) | 48 (21.1) | | | 47 (30.1) | 37 (23.7) | | | 17 (40.5) | 16 (38.1) | | |
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Note: and , and , and and all represent the allele distribution analysis between mother and father within the same subject group.
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