Parental Genetic Variants, MTHFR 677C>T and MTRR 66A>G, Associated Differently with Fetal Congenital Heart Defect

Table 5

Genotype distribution differences of MTHFR 677C>T, MTHFR 1298A>C, and MTRR 66A>G polymorphisms between control and CHD (VSD and non-VSD) mothers.

	MTHFR 677C>T			MTHFR 1298A>C			MTRR 66A>G
	CC	CT	TT	AA	AC	CC	AA	AG	GG
Control	36 (31.6)	48 (42.1)	30 (26.3)	89 (78.1)	24 (21.1)	1 (0.8)	67 (58.8)	44 (38.6)	3 (2.6)
Non-VSD	12 (15.4)	33 (42.3)	33 (42.3)	57 (73.1)	21 (26.9)	0 (0)	37 (47.4)	35 (44.9)	6 (7.7)
VSD	8 (38.1)	8 (38.1)	5 (23.8)	14 (66.7)	7 (33.3)	0 (0)	7 (33.3)	11 (52.4)	3 (14.3)
Non-VSD versus control	χ2	3.288	8.473		0.828	0.638		1.433	3.396
		0.070	0.004		0.363	1.000		0.231	0.138
	OR	2.063	3.300		1.366	0.989		1.440	3.622
	95% CI	0.937–4.542	1.454–7.488		0.697–2.679	0.967–1.011		0.792–2.621	0.856–15.330
VSD versus control	χ2	0.278	0.215		1.457	0.157		2.92	8.340
		0.598	0.643		0.227	1.000		0.088	0.004
	OR	0.750	0.750		1.854			2.393	9.571
	95% CI	0.257–2.189	0.222–2.535		0.673–5.107			0.862–6.643	1.615–56.736