Parental Genetic Variants, MTHFR 677C>T and MTRR 66A>G, Associated Differently with Fetal Congenital Heart Defect

Table 6

Genotype distribution differences of MTHFR 677C>T, MTHFR 1298A>C, and MTRR 66A>G polymorphisms between control and CHD (VSD and non-VSD) fathers.

	MTHFR 677C>T			MTHFR 1298A>C			MTRR 66A>G
	CC	CT	TT	AA	AC	CC	AA	AG	GG
Control	37 (32.5)	47 (41.2)	30 (26.3)	82 (71.9)	31 (27.2)	1 (0.9)	68 (59.6)	44 (38.6)	2 (1.8)
Non-VSD	12 (15.4)	39 (50.0)	27 (34.6)	55 (70.5)	21 (26.9)	2 (2.6)	47 (60.2)	25 (32.1)	6 (7.7)
VSD	8 (38.1)	9 (42.9)	4 (19.0)	16 (76.2)	4 (19.0)	1 (4.8)	7 (33.3)	12 (57.1)	2 (9.5)
Non-VSD versus control	χ2	5.778	5.931		0.001	0.855		0.389	3.553
		0.016	0.015		0.976	0.741		0.533	0.130
	OR	2.559	2.775		1.010	2.982		0.822	4.340
	95% CI	1.176–5.566	1.206–6.385		0.527–1.936	0.264–33.689		0.444–1.522	0.839–22.441
VSD versus control	χ2	0.052	0.544		0.484	1.575		3.782	6.221
		0.820	0.461		0.487	0.313		0.078	0.013
	OR	0.886	0.617		0.661	5.125		2.649	9.714
	95% CI	0.311–2.519	0.169–2.247		0.205–2.133	0.305–86.248		0.968–7.247	1.179–80.024