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BioMed Research International
Volume 2017, Article ID 3079141, 7 pages
Research Article

Foveal Avascular Zone in Normal Tension Glaucoma Measured by Optical Coherence Tomography Angiography

1Medical Faculty, Department of Ophthalmology, University of Nis, Nis, Serbia
2Ophthalmology Clinic, Clinical Center Nis, Nis, Serbia
3BATIGOZ Health Group Eye Clinic, Izmir, Turkey
4Department of Ophthalmology, Adnan Menderes University Medical School, Aydin, Turkey
5Medical Faculty, Department of Ophthalmology, University of Belgrade, Belgrade, Serbia
6Eye Clinic “Dr. Sefic”, Sarajevo, Bosnia and Herzegovina
7Center for Anesthesiology and Reanimatology, Clinical Center Nis, Nis, Serbia
8Department of Ophthalmology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia

Correspondence should be addressed to Svetlana Jovanovic; moc.oohay@civonavojanaltevsrd

Received 6 September 2017; Revised 22 November 2017; Accepted 27 November 2017; Published 17 December 2017

Academic Editor: Mitsuru Nakazawa

Copyright © 2017 Maja Zivkovic et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aim. To measure diameter of foveal avascular zone (FAZ), FAZ area, and vessel density using Optical Coherence Tomography Angiography (OCT-A) in patients with normal tension glaucoma (NTG) and to establish the possible role of OCT-A in diagnosis and follow-up of patients with NTG. Methods. Twenty-one eyes of 21 patients with NTG and 30 eyes of 30 healthy subjects underwent complete ophthalmic examination as well as OCT-A on ZEISS AngioPlex. macula scans were used to measure vertical, horizontal, and maximum diameter of FAZ by two graders. Mean values and interobserver variability were analyzed. Image J was used for analysis of FAZ area and vessel density. Results. Mean vertical diameter (, ), horizontal diameter (, ), maximum diameter (, ), and FAZ area (, ) were statistically significantly enlarged in the NTG group compared to those in the control group. Vessel density (, ) was statistically significantly decreased in the NTG group compared to that in the control group. Conclusion. OCT-A could have an important role in the future in diagnosis of patients with NTG. In patients with NTG, there is larger FAZ area, while the vessel density is reduced in comparison to the control group.