Nanomedicine for Inner Ear Diseases: A Review of Recent In Vivo Studies

Table 4

Studies attempting to deliver genes to the inner ear using nanoparticles.

Nanoparticle	Size of nanoparticle	Animal	Administration route	Loaded drug or gene	Evaluation time	Evaluation of nanoparticle uptake
PHEA NP [16]	103.1 nm	C57/BL6 mice	Intratympanic	GFP plasmid DNA and fluorescent dye	At 48 h	Confocal microscope
Dendrimer-based NP [33]	132 ± 20 nm	Sprague Dawley rats	Intratympanic	Atoh1-EGFP plasmid	At 7 days	Confocal microscope, RT-PCR, and Western blot

NP: nanoparticle; PHEA: poly(2-hydroxyethyl L-aspartamide).