Heterogeneity of Necrotic Changes between Cortical and Cancellous Bone in Mandibular Osteoradionecrosis: A Histopathological Analysis of Resection Margin after Segmental Mandibulectomy

Figure 4

Clinical and histopathological images of patient number 8. (a) A resected bone specimen. (b and c) Surgical findings. Bleeding was found at the anterior (b) and posterior (c) margins. (d) The cancellous bone at the anterior margin was viable. Cortical bone at the anterior margin (e) and cancellous bone at the posterior margin (f) were necrotic. (g) Cortical bone at the posterior margin was “heterogeneously necrotic.” The viable bone was found near the most advanced area of bone destruction (h), whereas the bone in the center of osteolysis was necrotic (i). (d′–i′) Enlarged views. All specimens were stained with hematoxylin and eosin, original magnification ×4.