Preoperative Gamma-Glutamyltransferase Is Associated with Cancer-Specific Survival and Recurrence-Free Survival of Nonmetastatic Renal Cell Carcinoma with Venous Tumor Thrombus
Table 1
Clinicopathological features of the 156 patients according to preoperative GGT.
Variables
All patients, (%) or median (IQR)
GGT, median (IQR), IU/L
p value
GGT ≥ 37.5 IU/L, (%)
GGT < 37.5 IU/L, (%)
value
Number of patients
156
—
—
39
117
—
Median (IQR) age, years
0.474
0.711
>60
76 (48.7)
23.0 (16.0–38.0)
20 (51.3)
56 (47.9)
<60
80 (51.3)
24.0 (16.3–37.0)
19 (48.7)
61 (52.1)
Median (IQR) BMI, kg/m2
0.808
0.358
>25
45 (28.8)
23.0 (16.5–37.0)
36 (30.8)
9 (23.1)
<25
111 (71.2)
23.0 (16.0–38.0)
81 (69.2)
30 (76.9)
Gender
0.138
0.610
Male
111 (71.2)
24.0 (17.0–38.0)
29 (74.4)
82 (70.1)
Female
45 (28.8)
21.0 (15.0–36.5)
10 (25.6)
35 (29.9)
Symptom presentation
0.346
0.054
Yes
100 (64.1)
23.0 (17.0–39.0)
30 (76.9)
70 (59.8)
No
56 (35.9)
23.0 (15.3–34.8)
9 (23.1)
47 (40.2)
ASA
0.883
0.696
1 + 2
133 (85.3)
23.0 (16.0–38.0)
34 (87.2)
99 (84.6)
3 + 4
23 (14.7)
26.0 (17.0–32.0)
5 (12.8)
18 (15.4)
Tumor laterality
0.826
0.779
Right
89 (57.1)
23.0 (16.0–38.0)
23 (59.0)
66 (56.4)
Left
67 (42.9)
23.0 (16.0–36.0)
16 (41.0)
51 (43.6)
Tumor thrombus level
0.002
0.010
RV
85 (54.5)
20.0 (15.5–32.0)
12 (30.8)
73 (62.4)
IVC
71 (45.5)
27.0 (20.0–45.0)
27 (69.2)
44 (37.6)
Maximum tumor width, cm
0.421
0.502
>10
57 (36.5)
24.0 (17.0–37.0)
16 (41.0)
41 (35.0)
<10
99 (63.5)
22.0 (15.0–42.0)
23 (59.0)
76 (65.0)
Pathological stage
0.004
0.001
T3a
80 (51.3)
20.0 (15.25–32.0)
11 (28.2)
69 (59.0)
T3b-4
76 (48.7)
26.0 (18.3–44.8)
28 (71.8)
48 (41.0)
Lymph node metastasis
0.814
0.480
Yes
19 (12.2)
23.0 (15.0–38.0)
6 (15.4)
13 (11.1)
No
137 (87.8)
23.0 (16.5–37.0)
33 (84.6)
104 (88.9)
Fuhrman grade
0.175
0.011
G1 + G2
91 (58.3)
23.0 (16.0–35.0)
16 (41.0)
75 (65.1)
G3 + G4
65 (41.7)
23.0 (17.0–46.0)
23 (59.0)
42 (35.9)
Histological subtypes
0.714
0.881
Clear-cell RCC
139 (89.1)
23.0 (16.0–38.0)
35 (89.7)
104 (88.9)
Non-clear-cell RCC
17 (10.9)
27.0 (16.5–39.0)
4 (10.3)
13 (11.1)
Sarcomatoid feature
0.114
0.010
Yes
27 (17.3)
28.0 (17.0–54.0)
12 (30.8)
15 (12.8)
No
129 (82.7)
23.0 (16.0–36.0)
27 (69.2)
102 (87.2)
GGT: gamma-glutamyltransferase; IQR: interquartile range; BMI: body mass index; ASA: American Society of Anesthesiologists; RV: renal vein; IVC: inferior vena cava; RCC: renal cell carcinoma.
