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BioMed Research International
Volume 2017, Article ID 3169179, 5 pages
Research Article

Low Molecular Weight Heparin Nebulization Attenuates Acute Lung Injury

1Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an 710038, China
2Department of Pharmaceutics, School of Pharmacy, The Fourth Military Medical University, Xi’an 710032, China

Correspondence should be addressed to Zhongping Gu; moc.361@dtgnipgnohzug and Xiaofei Li; moc.361@dtiefoaixil

Received 3 November 2016; Revised 11 March 2017; Accepted 14 March 2017; Published 15 May 2017

Academic Editor: Vasiliki Galani

Copyright © 2017 Nianlin Xie et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. As acute lung injury (ALI) caused high mortality rate, it is important to explore the protection and treatment of ALI. The aim of the current study is to evaluate the effect of low molecular weight heparin (LMWH) nebulization on attenuating acute lung injury and the associated mechanism. Methods. The arterial blood gas, total protein content in bronchoalveolar lavage fluid, lung wet/dry weight ratio, malondialdehyde (MDA) content, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity, and Akt phosphorylation were evaluated after the ALI rabbits were treated with or without LMWH nebulization. Results. PaO2 was increased and lung wet/dry weight ratio as well as total protein content in BALF was decreased after LMWH nebulization. After the application of LMWH nebulization therapy, the SOD and GSH-Px activity was rebounded and the increase of MDA content was significantly inhibited. The Akt protein phosphorylation level was decreased after LMWH nebulization therapy. Conclusions. LMWH nebulization treatment can relieve the traumatic ALI in rabbits and inhibit oxidative stress possibly by suppressing the Akt phosphorylation.