Platinum-Based Drugs Differentially Affect the Ultrastructure of Breast Cancer Cell Types

Figure 1

Representative SEM micrographs of breast cell lines. (a) Untreated normal breast cell line (MCF-10A). Cells are in contact with each other featured by short lamellipodia. (b) Breast cell lines (MCF-7, BT-474, and MDA-MB-231) treated with three types of PBDs, Cisplatin, Carboplatin, and Oxaliplatin, at 15-minute interval in comparison to the controlled group. Surface pores are illustrated by head arrow. Micrographs are screened at scale of 2–5 μM. (c) Breast cell lines (MCF-7, BT-474, and MDA-MB-231) treated with three types of PBDs, Cisplatin, Carboplatin, and Oxaliplatin, in comparison to the controlled group at 12-hour interval. Grooves and apoptotic features are indicated by head arrow. Micrographs are screened at scale of 1–10 μM.

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