Platinum-Based Drugs Differentially Affect the Ultrastructure of Breast Cancer Cell Types

Figure 2

The effect of PBDs on the ultrastructure of breast cancer cells by TEM. (a) TEM micrographs representing necrosis of posttreated cancer cells with PBDs. (b) TEM micrographs illustrating PBDs deposit around and within the fat droplets of cancer cells. (A) Fat droplet in untreated cells. (B) MCF-7 treated with Cisplatin at 10 μm for 2 h (50000x). (C) MCF-7 treated with Carboplatin at 20 μm for 2 h (15000x). (D) MCF-7 treated with Oxaliplatin at 20 μm for 2 h (30000x). (E) BT-474 cells treated with Cisplatin 20 μm for 4 h (12000x). (F) BT-474 treated with Oxaliplatin at 20 μm for 2 h (12000x). (G) MDA-MB-231 treated with Oxaliplatin at 10 μm for 2 h (40000x). (H) MDA-MB-231 treated with Carboplatin at 10 μm for 2 h (40000x). (c) TEM micrographs illustrating myelinated bodies observed on PBDs-treated cells (arrows). (A) and (B) Carboplatin treated MCF-7 at 10, 4 h (10000x). (C) BT-474 treated with Cisplatin at 20, 4 h (25000x). (D) BT-474 treated with Carboplatin at 10, 2 h (60000x). (E) MDA-MB-231 treated with Carboplatin at 10 for 4 h (50000x).

(a)

(b)

(c)