Corneal Nerve Fiber Structure, Its Role in Corneal Function, and Its Changes in Corneal Diseases

Table 1

Role of TRP channels in the cornea.

	TRPV1	TRPV3	TRPV4	TRPA1	TRPC4	TRPM8
Nociception	○			○
Regeneration	○	○			○
Inflammation	○		○
Fibrosis or scarring	○
Dry eye	○		○			○
Tissue location	Ner, Epi, End	Ner, Epi, End	Epi, End	Ner	Epi	Ner, Epi, End
Reference number	[24, 73–75, 109, 114–123]	[106, 107]	[124]	[24, 78–82]	[100]	[125–127]

○: TRP channels participating in physiological and pathophysiological conditions; Ner: corneal nerve, Epi: corneal epithelial cell, and End: corneal endothelial cell.