Early Effect of Amyloid β-Peptide on Hippocampal and Serum Metabolism in Rats Studied by an Integrated Method of NMR-Based Metabolomics and ANOVA-Simultaneous Component Analysis

<div>Effect of Aβ25–35 injection on hippocampal metabolism in rats analyzed by ASCA model: typical 1H NMR spectra in rat hippocampus after injection of (a) saline (b) and Aβ25-35 solutions; (c) ASCA score plot of the interaction effect of Aβ25–35 injection and time as well as (d) its corresponding loading plot. Con, the control group with saline injection; AD, the AD group with Aβ25–35 injection; Ala, alanine; Lac, lactate; GABA, γ-aminobutyric acid; NAA, N-acetylaspartate; Gln, glutamine; Glu, glutamate; Suc, succinate; Asp, aspartate; Cre, creatine; Cho, choline; Tau, taurine; m-Ins, myoinositol.</div>

BioMed Research International

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Figure 2: Early Effect of Amyloid β-Peptide on Hippocampal and Serum Metabolism in Rats Studied by an Integrated Method of NMR-Based Metabolomics and ANOVA-Simultaneous Component Analysis

Figure 2 | Early Effect of Amyloid β-Peptide on Hippocampal and Serum Metabolism in Rats Studied by an Integrated Method of NMR-Based Metabolomics and ANOVA-Simultaneous Component Analysis 