Early Effect of Amyloid β-Peptide on Hippocampal and Serum Metabolism in Rats Studied by an Integrated Method of NMR-Based Metabolomics and ANOVA-Simultaneous Component Analysis

<div>Effect of Aβ25–35 injection on serum metabolism in rats analyzed by ASCA model: typical 1H NMR spectra in rat serum after injection of (a) saline (b) and Aβ25-35 solutions; (c) ASCA score plot of the interaction effect of Aβ25–35 injection and time as well as (d) its corresponding loading plot. Con, the control group with saline injection; AD, the AD group with Aβ25–35 injection; LDL/VLDL, low-density lipoproteins and very low-density lipoproteins; Val, valine; Lac, lactate; Ala, alanine, NAG, N-acetylglycoprotein; OAG, O-acetylglycoprotein; Gln, glutamine; Cre, creatine; Tyr, tyrosine; His, histidine; For, formate.</div>

BioMed Research International

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Figure 3: Early Effect of Amyloid β-Peptide on Hippocampal and Serum Metabolism in Rats Studied by an Integrated Method of NMR-Based Metabolomics and ANOVA-Simultaneous Component Analysis

Figure 3 | Early Effect of Amyloid β-Peptide on Hippocampal and Serum Metabolism in Rats Studied by an Integrated Method of NMR-Based Metabolomics and ANOVA-Simultaneous Component Analysis 