The Correlation of Decreased Heart Rate Recovery and Chronotropic Incompetence with Exercise Capacity in Idiopathic Pulmonary Arterial Hypertension Patients
Table 2
Summary of demographics, PFT, and CPET of IPAH patients with HRR1 < 16 and HRR1 ≥ 16.
IPAH patients with HRR1 < 16
IPAH patients with HRR1 ≥ 16
Demographics
31
27
Sex (F/M)
22/9
15/12
>0.05
Age (y)
37.7 ± 13.4
32.7 ± 14.1
>0.05
BMI (kg/m2)
22.4 ± 3.3
22.6 ± 5.2
>0.05
PFT
FVC (L)
2.8 ± 0.9
3.2 ± 0.9
>0.05
FVC% pred
80.2 ± 16.1
84.0 ± 14.5
>0.05
FEV1 (L)
2.2 ± 0.7
2.6 ± 0.7
<0.05
FEV1% pred
74.6 ± 13.8
80.8 ± 15.7
>0.05
FEV1/FVC (%)
78.1 ± 7.9
82.8 ± 6.0
<0.05
FEF25 (L/s)
4.5 ± 2.1
5.1 ± 1.9
>0.05
FEF25%
70.4 ± 24.5
75.8 ± 17.9
>0.05
FEF50 (L/s)
2.4 ± 1.2
3.4 ± 1.4
<0.05
FEF50%
59.6 ± 24.7
75.9 ± 24.7
<0.05
FEF75 (L/s)
0.8 ± 0.6
1.4 ± 1.1
<0.05
FEF75%
41.6 ± 24.0
62.3 ± 29.6
<0.05
DLco (% pred)
61.1 ± 12.3
70.5 ± 16.3
<0.05
Clinical parameters
NYHA FC
<0.05
(%)
11 (35.5%)
22 (81.5%)
(%)
20 (64.5%)
5 (18.5%)
NT-proBNP (pg/ml)
1354.7 ± 1613.4
365.4 ± 358.4
<0.01
6MWD (m)
443.8 ± 84.0
489.3 ± 69.3
<0.05
Background therapy
>0.05
Sildenafil,
8
9
Tadalafil,
3
3
Vardenafil,
4
5
Bosentan,
8
6
Ambrisentan,
4
2
Ventavis,
4
2
RHC
SBP, mmHg
119.0 ± 18.0
109.5 ± 16.9
>0.05
DBP, mmHg
74.6 ± 13.2
72.1 ± 14.6
>0.05
mPAP, mmHg
58.8 ± 13.2
59.0 ± 15.4
>0.05
mRAP, mmHg
6.5 ± 4.1
9.2 ± 4.7
<0.05
CO, l/min
4.5 ± 1.2
4.9 ± 2.0
>0.05
CRI, l/min/m2
2.9 ± 0.8
2.9 ± 1.0
>0.05
PVR, mmHg
12.5 ± 5.8
12.8 ± 7.0
>0.05
PAWP, mmHg
7.9 ± 3.5
8.4 ± 3.8
>0.05
CPET
HRR1 (bpm)
10.9 ± 3.8
23.7 ± 6.8
<0.01
HR at baseline (bpm)
89.2 ± 12.4
80.9 ± 10.1
<0.01
HR at end (bpm)
135.7 ± 22.2
146.4 ± 19.2
>0.05
ΔHR(bpm)
46.4 ± 19.3
65.5 ± 19.2
<0.01
HR 1 min post (bpm)
124.6 ± 21.7
123.1 ± 19.9
>0.05
HRR1 (bpm)
11.0 ± 4.0
23.3 ± 6.8
<0.01
CR
0.5 ± 0.29
0.6 ± 0.2
<0.01
CRI ()
28 (90.3%)
24 (88.9%)
>0.05
Peak Load (W)
56.3 ± 22.8
75.6 ± 26.9
<0.01
Peak VO2 (ml/min)
689.4 ± 210.8
891.2 ± 286.2
<0.01
Peak VO2% pred
37.2 ± 11.2
45.9 ± 11.0
<0.01
Peak HR (beats/min)
136.5 ± 22.5
145.1 ± 18.7
>0.05
Peak (L/min)
42.3 ± 18.2
45.3 ± 13.7
<0.05
Peak BF (breaths/min)
34.1 ± 7.4
33.5 ± 6.9
>0.05
Peak O2 pulse (ml/beat)
5.2 ± 1.7
6.20 ± 1.9
<0.05
Peak PET CO2
23.5 ± 9.4
25.7 ± 6.6
>0.05
Peak PET O2
127.4 ± 9.7
124.9 ± 6.5
>0.05
VE/VCO2 Slope
42.0 ± 12.0
41.0 ± 8.3
>0.05
Values are expressed as mean ± SD. , , versus IPAH patients with HRR1 ≥ 16 using unpaired -test. NT-proBNP = n-terminal natriuretic peptide type-B; FC = New York Heart Association functional classification; 6MWD = 6-minute walking distance; PETCO2 = partial pressure of end-tidal carbon dioxide; PETO2 = partial pressure of end-tidal oxygen; SBP = systolic blood pressure; DBP = diastolic blood pressure; other abbreviation definitions are same as Table 1.
