Genotyping the High Altitude Mestizo Ecuadorian Population Affected with Prostate Cancer

Table 2

Genotype distribution and allele frequency of polymorphisms in SRD5A2, MTHFR, and AR genes in high altitude Ecuadorian population with prostate cancer.

Gene	Polymorphism	Genotype	Genotypic frequency			Allele frequency
			Control	Case	All	Control	Case	All
SRD5A2	A49T	A/A	0.347	0.289	0.322	0.674	0.553	0.627
		A/T	0.653	0.526	0.597
		T/T	0.000	0.184	0.081	0.326	0.447	0.373
	V89L	V/V	0.153	0.404	0.264	0.469	0.684	0.564
		V/L	0.632	0.561	0.601
		L/L	0.215	0.035	0.136	0.531	0.316	0.436
MTHFR	C677T	C/C	0.473	0.288	0.383	0.732	0.639	0.687
		C/T	0.518	0.702	0.607
		T/T	0.009	0.010	0.009	0.268	0.361	0.313
AR	CAG repeats	≥22 CAGs	0.639	0.372	0.484
		≤21 CAGs	0.361	0.628	0.516
	GGC repeats	≥17 GGCs	0.389	0.281	0.329
		≤16 CAGs	0.611	0.719	0.671