XBP1-Mediated BiP/GRP78 Upregulation Copes with Oxidative Stress in Mosquito Cells during Dengue 2 Virus Infection

Figure 3

Dengue 2 virus (DENV2) activates XBP1 expression and its splicing activity in C6/36 cells. In C6/36 cells without infection by DENV2, most XBP1 mRNA was intact (unspliced), while its spliced form was seen at 24 h postinfection (hpi) and had risen to a higher level by 96 hpi. This indicates that the endoplasmic reticular (ER) stress induced by DENV2 in mosquito cells also triggers, in addition to BiP/GRP78 expression, XBP1 mRNA expression and its splicing activity.