Risk Factors of Delirium in Sequential Sedation Patients in Intensive Care Units
Table 2
Univariate Cox proportional regression of ICU delirium in sequential sedation patients.
Variables
RR
95% CL
Age (≥51)
1.957
1.112–3.444
0.020
Allergic history
2.013
0.626–6.467
0.240
Regular drinking
1.078
0.613–1.895
0.795
Regular smoking
1.580
0.908–2.750
0.106
Hypertension
1.249
0.642–2.430
0.513
APACHE II (≥23)
1.146
0.621–2.115
0.663
SOFA score (≥14)
1.801
1.016–3.190
0.044
The first dose of midazolam (mg/kg/d)
1.095
0.833–1.438
0.515
The first dose of fentanyl (μg/kg/d)
1.040
1.004–1.077
0.030
The maintenance dose of midazolam (mg/kg/d)
1.048
1.001–1.097
0.043
The maintenance dose of fentanyl (μg/kg/d)
1.025
1.004–1.047
0.021
The accumulated dose of midazolam (mg)
1.000
0.999–1.001
0.960
The accumulated dose of fentanyl (mg)
0.968
0.916–1.023
0.252
Time of patients meeting sequential criteria to stop sedation
1.003
0.995–1.011
0.486
Time of patients meeting sequential criteria for extubation
1.002
0.995–1.009
0.635
Sequential sedatives
Midazolam (group M-M)
1.000
Ref.
Propofol (group M-P)
0.863
0.456–1.634
0.652
Dexmedetomidine (group M-D)
0.451
0.217–0.939
0.033
Patients at ICU admission (before meeting the sequential criteria). When patients met the sequential criteria. After patients met the sequential criteria for extubation. ,.
