Inhibitors of Histone Deacetylases Are Weak Activators of the FMR1 Gene in Fragile X Syndrome Cell Lines

Table 1

Expression of FMR1 gene in different cell lines depending on treatment (values relative to FMR1 expression in GM06895, see Materials and Methods).

Cell lines	(a) 5-azadC		(b) HDAC inhibitors
	Untreated	Treatment	Untreated	DMSO	Trichostatin A	Vorinostat
Control
GM06895	1.02 ± 0.30	12.09 ± 3.27	1.00 ± 0.11	1.11 ± 0.05	1.36 ± 0.15	1.41 ± 0.08
GM06865	5.57 ± 1.19	10.48 ± 0.22	9.50 ± 2.85	7.36 ± 1.10	9.85 ± 1.86	6.05 ± 2.59
FXS
GM04025	0	4.97 ± 0.20	0	0	0.06 ± 0.01	0.14 ± 0.07
CPG7	0	0.30 ± 0.05	0	0	0	0