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BioMed Research International
Volume 2017 (2017), Article ID 3585809, 8 pages
Research Article

Bisphenol A Exposure during Pregnancy Alters the Mortality and Levels of Reproductive Hormones and Genes in Offspring Mice

1College of Animal Science and Technology, Agricultural University of Hebei, Baoding 071001, China
2College of Traditional Chinese Veterinary Medicine, Agricultural University of Hebei, Baoding 071001, China

Correspondence should be addressed to Xiuhui Zhong

Received 17 January 2017; Revised 25 February 2017; Accepted 28 February 2017; Published 14 March 2017

Academic Editor: Masood Ahmad

Copyright © 2017 Shuang Ma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The present study investigated the reproductive toxicity of bisphenol A (BPA) exposure to the mother on the offspring mice. BPA was given to pregnant mice at 50 mg/kg, 500 mg/kg, and 2500 mg/kg BW BPA daily by gavage during the whole gestation period. The offspring mice were sacrificed at 8 weeks of age. Results showed that exposure of BPA to the mother increased the mortality (). Maternal exposure of BPA reduced the levels of T (♂) and FSH (♀) () and elevated E2 (♀) level in the adult offspring (). BPA exposure caused testicular damage as shown by less Leydig cells and ovarian injury as shown by more vacuoles and less corpus granules in the adult offspring mice. Immunohistochemistry revealed that maternal exposure of BPA increased Bax and decreased Bcl-2 at the protein levels in testicular and ovary tissues in the offspring mice. BPA significantly reduced the expression of StAR in male offspring (). Interestingly, the mRNA levels of Cyp11a were significantly decreased in 50 mg/kg groups and were increased in 500 mg/kg group in the males. Reduced Kitlg and elevated Amh at the mRNA levels were detected in the female offspring.